Sirtuin

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 Sirtuin localization Enzyme activity Function

SIRT1 Nucleus NAD-dependent Deacetylase Metabolism/Aging/Cancer/Neural differentiation/ rRNA synthesis
SIRT2 Cytoplasm NAD-dependent Deacetylase Cell cycle/Adipogenesis/Neurodegeneration
SIRT3 Mitochondria NAD-dependent Deacetylase Mitochondrial deacetylation
SIRT4 Mitochondria ADP-ribosyl-transferase Mitochondrial deacetylation/Insulin metabolism
SIRT5 Mitochondria NAD-dependent Deacetylase Urea cycle
SIRT6 Nucleus NAD-dependent Deacetylase ADP-ribosyl-transferase Genome instability/ Telomeric chromatin
SIRT7 Nucleolus ? Heart phenotype/ RNA polI Transcription
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